A1581 Cancer incidence in the cohort of Chernobyl accident fighters

Monday, March 19, 2012: 14:55
Bacalar 2 (Cancun Center)
Ilya Veyalkin, Cancer Contol, N.N. Alexandrov National Cancer Center Of Belarus, Minsk Area, Belarus
Vladimir Masyakin, Epidemiology, Republican Researh and Practical Center of Radiation Medicine and Human Ecology, Homel, Belarus
Alexey Okeanov, Radiation Hygiene, International Sakharov Environmental Universuty, Minsk, Belarus
Eldar Nadyrov, Administration, Republican Researh and Practical Center of Radiation Medicine and Human Ecology, Homel, Belarus
Yury Averkin, Cancer Contol, N.n. Alexandrov National Cancer Center Of Belarus, Minsk area, Belarus
Handouts
  • veyalkin ilya.pdf (1018.0 kB)
    • Introduction
    Discussion about radiation effects on population has not been stopped for 25 years after the well known disaster at the Chernobyl Nuclear Power Plant (26.04.1986). Thus the purpose of this work was to estimate the cancer incidence in the cohort of people who were occupied in the fighting of disaster outcomes.

    Methods
    The cohort of Chernobyl Accident Fighters (CAF) which were identified from Belorussian State Chernobyl Register and Belorussian Republican Cancer Registry was investigated for cancer incidence. The cohort contains 93 357 CAF. The cohort was followed up since 01.01.1993 till 31.12.2006. Standardized incidence ratios (SIRs) were calculated using the adjusted (by age, sex, residence and calendar time) Belorussian population cancer incidence rates to generate expected numbers.

    Results
    There was found a little excess of cancer cases of all sites (SIR=1,06; 95%CI=1,03-1,09 in males and SIR=1,15; 95%CI=1,09-1,22 in females). But that was due to significantly high incidence of thyroid cancer (SIR=4,67; 95%CI=4,04-5,4 in males and SIR=3,28; 95%CI=2,78-3,87 in females). After exclusion of thyroid cancer compound we have got no difference in cancer incidence (SIR=1,03; 95%CI=0,99-1,06 in males and SIR=1,05; 95%CI=0,99-1,12 in females). Also certain significant excess in cancer incidence in the investigated cohort was found in males colon cancer (SIR = 1,24; 95%CI=1,04¸1,48); kidney cancer (SIR = 1,28; 95%CI=1,09¸1,52); bladder cancer (SIR = 1,22; 95%CI=1,02¸1,47) and leucosis (SIR= 1,42; 95%CI=1,15¸1,75); skin cancer (SIR = 1,29; 95%CI=1,14¸1,47 in males and SIR = 1,59; 95%CI=1,31¸1,94 in females). No excess in breast cancer (SIR = 0,93; 95%CI=0,81¸1,08) and lung cancer (SIR = 0,84; 95%CI=0,79¸0,9 in males) were shown.

    Discussion
    Strong evidence of high risk of thyroid cancer in the study cohort was shown. These data are conforming to investigations of another group of people suffered from the Chernobyl accident.

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