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In the end of 80th 25 cases of carcinoma of skin of the arm (C44.6) in workers of Polotsk Glass Fiber Enterprise were occasionally found by us. Most cases of cancer were at the stage of distant metastasis and bad prognosis. All affected workers were operators and had a long term direct professional contact with lubricating agent N80. The purpose of this work was to estimate the possibility of determination of localization of carcinogenically dangerous production by data of Belorussian cancer registry.
Methods
Skin cancer in two close settled cities Polotsk and Novopolotsk and whole Belorussian urban population was estimated by data of Belorussian Cancer Registry for 1990-2006. Standardized incidence ratios (SIRs) were calculated using the Belorussian urban population incidence rates to generate expected numbers.
Results
There are high numbers of cancer cases with specific localization and morphology, younger mean age of patients and plurality of tumors. According to Atlas of Skin cancer SIR distribution Polotsk region seems to have high skin cancer risk in compare with other Belorussian areas. The proportions of C44.6 localization were 6,5% in Polotsk, 4,3% in Novopolotsk and 3,9% in Belarus. But in the same time among C44.6 cases the proportions of carcinoma were 66% in Polotsk, 32% in Novopolotsk and 20% in Belarus. The next feature is the number of plural primary malignant tumors (10 double and 4 triple of metachronous tumors C44.6 in Polotsk against 1 of double tumors in Novopolotsk). The mean age of diseased of carcinoma C44.6 was 55,0 in Polotsk and 62,7 in Novopolotsk and 68,7 years in Belarus. SIR of C44.6 for Polotsk (SIR=2,18; 95%CI=1,67-2,82) and Novopolotsk (SIR=1,58; 95%CI=1,11-2,18) were significantly higher than in whole population.
Discussion
We have designed some criteria for primary identification of occupational risk factors in small towns based on data of Population Cancer Registry.