A1075 Dependence of the impact of chrysotile fibers to the organism from its physical and chemical properties

Tuesday, March 20, 2012
Ground Floor (Cancun Center)

Serik Ibrayev, Scientific Center, Karaganda State Medical University, Karaganda, Kazakhstan
Ibrayev Serik, Scientific Center, Karaganda State Medical University, Karaganda, Kazakhstan
Otarov Ertay, Scientific Center, Karaganda State Medical University, Karaganda, Kazakhstan
Zeinidenov Assylbek, Scientific Center, Karaganda State Medical University, Karaganda, Kazakhstan
Introduction
The impact of some types of asbestos dust leads to the development of asbestosis. Investigations of chemical stability show that chrysotile asbestos subjected to the impact of various chemical factors, as well as environmental factors, change the physical and chemical characteristics, structure and chemical composition of fibers. The purpose of the work. To reveal the dependence of biological activity of chrysotile asbestos fibers on physical and chemical properties of their surface under the influence of certain environmental factors.

Methods
Study of physical and chemical properties, the analysis of microstructural characteristics and getting imagy of surface of the studied samples was conducted with using a scanning electron microscope Tescan Vega (Czech Republic) with energy dispersive analyzer INCAPentaFET-x3 (England).

Results
The results of the investigation showed the presence of nano-sized rods of chrysotile asbestos fibers, size between 94 to 167 nanometers. The background spectrum of chrysotile asbestos fibers showed the following elemental composition of the investigated fiber (% weight): O – 52.70; Mg – 25.09; Al – 0.67; Si – 20.18; Fe – 1.35. At processing a sample of chrysotile fibers with distilled water the changes in its chemical composition compared with the background composition of chrysotile asbestos are revealed (% weight): O – 51.49; Mg – 20.82; Al – 0.42; Si – 15.11; Fe – 1.48 in the form of reduced structure-forming elements - magnesium and silicon.

Discussion
The biological activity of chrysotile asbestos fibers may depend on the particles size and changing at the same time their physical and chemical properties. Scanning electron microscopy determines chrysotile fibers as nanomaterial, in the form of nanotubes. Impact of certain environmental factors leads to a change in their chemical composition, morphological and structural characteristics, as well as physical and chemical properties of their surface and alters their ability to have a negative impact to the organizm.  

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