Results. Peri- and postmenopausal women increased their physical activity (27.5% and 26.8%) during eight-year follow up period more often than premenopausal (17,8%) women (p=0.07). Menopausal status was not significantly correlated with change of quality of life. Women who increased their physical activity, had 1.5 times greater odds to improved quality of life than women whose physical activity decreased. Quality of life improved among women whose weight remained stable compared to women whose weight increased during the follow-up (OR 1.26, 95% CI 1.07 to 1.50). Conclusion. Physical activity increase is correlated with improvement of global QoL among menopausal women in a prospective design, regardless of menopausal status. The importance of the finding to the work-related factors will be discussed in the presentation.