Methods: We identified relevant randomised controlled trials (RCTs) and cohort studies, published since 1990, by screening citations from 35 earlier systematic reviews and by searching Medline and Embase to April 2010. We estimated effects by type of intervention and other features, including study quality.
Results: Among 42 finally included studies, 27 assessed return to work (RTW), 21 duration of sickness absence, and five job loss. Interventions included prescribed exercises, behavioural change techniques, workplace modifications and provision of extra services. Studies tended to be small (median sample size 107 (inter-quartile range (IQR) 77 to 148) and of limited quality. Most interventions appeared beneficial. The median relative risk (RR) for RTW was 1.21 (IQR 1.00 – 1.60) and that for avoiding MSD-related job loss, 1.25 (IQR 1.06-1.71). The median reduction in sickness absence was 1.11 (IQR 0.32 to 3.20) days/month. Effects were smaller, however, in larger better quality studies, suggesting possible publication bias. No intervention type was clearly superior to others, although effort-intensive interventions were less effective than simple ones. No study established statistically significant net economic benefits.
Conclusions: Benefits are generally small and of uncertain cost-effectiveness. Expensive interventions should be implemented only with careful cost-benefit evaluation planned from the start. Future research should focus on the cost-effectiveness of simple low cost interventions, and impacts on job retention.