A1263 Blood cadmium and chronic kidney disease in Korean adults: analysis of KNHANES 2005-2008

Monday, March 19, 2012
Ground Floor (Cancun Center)
Hyoung-ryoul Kim, Department of Occupational and Environmental Medicince, The Catholic University of Korea, College of Medicine, Seoul, South Korea
Jun Pyo Myung, Department of Occupational and Envrionmental Medicine, The Catholic University Of Korea, College Of Medicine, Seoul, South Korea
Dean Baker, Center for Occupational and Environmental Health, University of California, Irvine, Irvine, United States
Introduction
The objective of this study was to evaluate the association between blood cadmium and chronic kidney disease in the Korean population using a representative sample.

Methods
A cross-sectional study was adopted to evaluate the association between blood cadmium and chronic kidney disease. Based on the Korean National Health and Nutrition Examination Survey (2005-2008), individual blood cadmium was measured in 3,012 adults aged 20 to 65 years.

Results
After adjustment for survey years, age, sociodemographic factors, and health behaviors, the odds ratios for reduced estimated glomerular filtration rate (eGFR) (<60 mL/minute per 1.73 ?), was 2.26 (95% confidence interval (CI): 1.29-3.96) when comparing the highest with the lowest blood cadmium quartile. After gender stratification, the odds ratios comparing participants in the highest with the lowest quartile of cadmium was 1.92 (95% CI: 1.02-3.87) for Korean females.

Discussion
These findings support the consideration of cadmium as a risk factor for chronic kidney disease in the general population. Furthermore, environmental heavy metal monitoring and an institutional strategy should be implemented to reduce Cd exposure in the general population.

See more of: Occupational Exposure to Toxic Metals
See more of: Poster
<< Previous Abstract | Next Abstract >>